I was stuck with this error when starting BizTalk host instances after database connectivity was lost and resumed,
A failure occurred when executing a Windows service request.
Service request: Start
BizTalk host name: BizTalkServerApplication
Windows service name: BTSSvc$BizTalkServerApplication
Additional error information:
Error code: 0x80131604
Error source: mscorlib
Error description: Exception has been thrown by the target of an invocation.
one of possible reasons (among other is a reported issue in BizTalk – and MS provides CU for it) is a new section in BizTalk config file that is not declared in machine.config. In my case, I added a new config section to define appSettings configuration keys – but I forgot to update machine.config first